Nano-Biophysics – University of Copenhagen

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Condensed Matter Theory > Research > Nano-Biophysics

The detection of light from /single/ proteins in a cellular environment, such as cell membranes and the interior of vesicles, poses great challenges. E.g. the chemical reactions catalyzed by the protein forms a sequence of seemingly random events, but a detailed statistical analysis reveal important systematics, which can tell a lot about the detailed functioning of the protein in different environments.

This unique piece of Nanoscience combining state of the art experiments and sofisticated theory gives new possibilities in the study of biological systems.

Selected publications:

Hatzakis, Nikos, Wei, Li, Jørgensen, Sune, Kunding, Andreas, Bolinger, Pierre-Yves, Ehrlich, Nicky, Makarov, Ivan, Skjot, Michael, Svendsen, Allan, Hedegård, Per, Stamou, Dimitrios, Single Enzyme Studies Reveal the Existence of Discrete Functional States for Monomeric Enzymes and How They Are "Selected" upon Allosteric Regulation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 134 Issue: 22 Pages: 9296-9302, 2012

Hatzakis, Nikos, Wei, Li, Jørgensen, Sune, Kunding, Andreas, Hedegård, Per, Stamou, Dimitrios, Regulation of Enzymatic Activity Occurs by Selection of Discrete Activity States BIOPHYSICAL JOURNAL Volume: 100 Issue: 3 Supplement: 1 Pages: 194-194 Published: FEB 2 2011

Bhatia, Vikram K., Madsen, Kenneth L., Bolinger, Pierre-Yves, Kunding, Andreas, Hedegård, Per, Gether, Ulrik, Stamou, Dimitrios, Amphipathic motifs in BAR domains are essential for membrane curvature sensing EMBO JOURNAL Volume: 28 Issue: 21 Pages: 3303-3314 DOI: 10.1038/emboj.2009.261 Published: NOV 4 2009

Hatzakis, Nikos S., Bhatia, Vikram K., Larsen, Jannik, Madsen, Kenneth L., Bolinger, Pierre-Yves, Kunding, Andreas H., Castillo, John, Gether, Ulrik, Hedegård, Per, Stamou, Dimitrios, How curved membranes recruit amphipathic helices and protein anchoring motifs NATURE CHEMICAL BIOLOGY Volume: 5 Issue: 11 Pages: 835-841 DOI: 10.1038/nchembio.213 Published: NOV 2009.